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Objective To study influence of tongxinluo on blood endothelial microparticles(EM Ps) and matrix metalloprotei‐nase‐9(MMP‐9) in patients with acute myocardial infarction after percutaneous coronary intervention(PCI) .Methods One hundred and twenty‐eight hospitalized patients with acute myocardial infarction after per‐cutaneous coronary intervention were recruited from January 2012 to December 2014 ,All patients were randomly divided into tongxinluo group (n=65) and control group (con‐ventional treatment ,n=63) .Tongxinluo group was on the basis of conventional treatment group with tongxinluo capsules 2 plus ,3 times a day .We detected the EMPs and MMP‐9 of two groups preoperatively and on the 7th postoperatively day .Results Com‐pared with the conventional treatment group ,blood EMPs and MMP‐9 in tongxinluo group were lower after 7 days treatment ,the difference was statistically significant (P<0 .05) .There was a positive correlation between the EMPs and MMP‐9(P<0 .05) .Con‐clusion For patients with acute myocardial infarction after percu‐taneous coronary intervention ,tongxinluo could further inhibit in‐flammatory reaction ,make the plaque stability and improve the function of endothelial cells on the basis of conventional treatment groups .
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Objective: To study significance of detection of serum levels of high sensitive C reactive protein (hsCRP), tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) for assessing patient’s condition in patients with coronary heart disease (CHD). Methods: Serum levels of hsCRP, TNF-α and IL-8 were measured in 78 CHD patients undergoing percutaneous coronary intervention (PCI) before and three months after PCI. Among CHD patients, there were 17 patients with acute myocardial infarction (AMI), 36 patients with unstable angina pectoris (UAP) and 25 patients with stable angina pectoris (SAP). Their levels of above indicators were compared with those of 47 healthy subjects (normal control group). Results: （1）Compared with normal control group, there were significant increase in serum levels of hsCRP [ (1.96±0.60) mg/L vs. (22.43±9.68) mg/L, (18.27±8.56) mg/L], TNF-α [ (11.26±3.82) ng/L vs. (60.12±19.37) ng/L, (40.33±15.48) ng/L] and IL-8 [ (48.26±20.87) ng/L vs. (120.36±33.32) ng/L, (105.92±34.2) ng/L] in AMI group and UAP group before treatment (P0.05 all). Conclusions: Detections of serum levels of hsCRP, TNF-α and IL-8 in CHD patients are of certain significance for diagnosis, treatment and prognosis prediction of CHD.
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Objective To study the influence of walking exercise training on heart function, left heart ventricle structure and plasma brain natriuretie peptide (BNP) concentration in patients with chronic heart failure ( CHF), to explore the sense of exercise training.Methods A total of 223 CHF patients were randomly assigned to a guided rehabilitation group, a non-guided rehabilitation group and a control group.All patients were given basic medicine treatment, and the guided rehabilitation group was administered guided walking exercise training program, while the non-guided rehabilitation group was encouraged to do exercise freely but with no guidance.Blood pressure, 6 min walking distance test, plasma concentration of BNP and echocardiography were measured in all patients before and after exercise training.Results At entry to the study, there was no significant difference among the 3 groups with regard to blood pressure, 6 rain walking distance and BNP level as well as echocardiographic parameters including left ventrieular ejection fraction (LVEF) and left ventricular end-diastolic diameter (LVEDd).A follow-up at the 6th month after intervention, the amount of readmission patients in guided rehabilitation group were significantly less than those in non-guided rehabilitation and control groups ( P < 0.05 ).It was also revealed that the plasma concentration of BNP decreased significantly ( P < 0.01 ) ; LVEF and 6 min walking distance improved significantly ( P < 0.01 ) in the guided rehabilitation group when compared with baseline and 6-month follow-up of the non-guided rehabilitation and control groups.However, there observed no significant change with regard to LVEDd.Conclusion Walking exercise training can improve exercise endurance in CHF patients and is safety; but has no influence on left heart ventricular structure in short time.